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The rash may become scaly and buy 2.5 mg prinivil prehypertension pediatrics, rarely order generic prinivil on-line pulse pressure 60, itchy; In children the disorder is often self-limiting purchase 5 mg prinivil visa blood pressure low, but in eventually that on the light-exposed areas and overly- adults it may be prolonged and progressive order prinivil once a day atrial fibrillation guidelines. Myositis may lead to permanent weakness and immo- bility, and inammation to contractures or cutaneous calcinosis. Long-term and regular Other connective tissue disorders may look similar, follow-up is necessary. Myopathy can be In this disorder the skin becomes hard as connective a side-effect of systemic steroids, so weakness is not tissues thicken. In addition Investigations there is intimal thickening of arterioles and arteries. About 30% of adults with dermatomyositis also These processes are not conned to the skin, but involve have an underlying malignancy. Adult dermatomyositis or The cause of systemic sclerosis is unknown but polymyositis therefore requires a search for such an many, apparently unrelated, pieces of the complex underlying malignancy. Toxoplasmosis rapeseed oil in Spain and dimerised l-tryptophan for should be excluded by serology. Environmental factors may also be rel- evant in isolated cases; changes like those of systemic Treatment sclerosis have affected workers exposed to polyvinyl Systemic steroids, often in high doses (e. Fibrosis of the lungs leads to dyspnoea, and brosis of the heart to congestive failure. The kidneys are involved late, but this has a grave prognosis in chronic graft-vs. Complications Investigations Most complications are caused by the involvement of The diagnosis is made clinically because histological organs other than the skin, but ulcers of the ngertips abnormalities are seldom present until the physical and calcinosis are distressing (Fig. Barium studies are best avoided as obstruc- Differential diagnosis tion may follow poor evacuation. Other contrast media Other causes of Raynaud s phenomenon are given are available. The differential diagnosis includes of muscle enzymes and immunoglobulin levels, and chilblains (p. Changes like those of progressive systemic sclerosis Systemic steroids, salicylates, antimalarials and long- affect workers exposed to polyvinyl chloride mono- term penicillin are used, but are not of proven value. The mnemonic stands for Calcinosis, Raynaud s phenomenon, oEsophageal dysmotility, Sclerodactyly and Telangiectasia. Telan- giectasia is peri-ungual on the ngers and at, mat- like or rectangular on the face. Many patients with this syndrome develop a diffuse progressive systemic sclerosis after months or years. Localized areas of skin become indurated, sometimes after an upper respiratory tract infection or prolonged renal function. Recently, there have been sinophilia are present and a deep skin biopsy, which promising reports of the efcacy of ultraviolet A-1 includes muscle, shows that the fascia overlying the (340 400 nm) phototherapy for affected skin in muscle is thickened. The disease responds promptly to systemic steroids; the long-term prognosis is good but disability in the short term can be severe. In a young child this can lead to facial Morphoea is a localized form of scleroderma with hemiatrophy. Its prognosis is usu- condition may cause stenosis of the urethral meatus, ally good, and the brosis slowly clears leaving slight and adhesions between the foreskin and glans of the depression and hyperpigmentation. Alopecia is mild and the hair fall mimics Many think that this condition is related to morphoea, telogen efuvium. About 25% of non-indurated white shiny macules, sometimes with patients have a small vessel vasculitis with palpable obvious plugging in the follicular openings. Women purpura, leg ulcers and painful dermal nodules on the are affected far more often than men and, although hands or elbows. Many show Raynaud s phenomenon, any area of skin can be involved, the classical ivory- arthritis, serositis and myositis. The skin lesions (keratoderma blenorrhagicum) are psoriasis-like red scaling plaques, often studded with vesicles and pus- Investigations tules, seen most often on the feet. The toes are red and Patients with mixed connective tissue disease have anti- swollen, and the nails thicken. Psoriasiform plaques bodies in high titre directed against one or more extract- may also occur on the penis and scrotum, with redness able nuclear antigens. Only one-third of patients have subepidermal immunoglobulin deposits in involved skin. The most common skin causes but a similar appearance: some are listed in manifestations are marble-like nodules near joints. Rest, elevation of affected Supercial and migratory thrombophlebitis extremities and local heat often help symptoms. Advances in Dermatology 6, 309 into the systemic circulation to cause fat in the skin 329. For con- venience, disorders of the blood vessels are grouped according to the size and type of the vessels affected. Disorders involving small blood vessels Acrocyanosis This type of poor circulation, often familial, is more common in females than males. The condition is caused by arteriolar constriction and dilatation of the subpapil- toes and, rarely, ears (Fig. They arrive with lary venous plexus, and to cold-induced increases in winter and are induced by cold. Chilblains are caused by a combination of arteriolar and venular constriction, the latter predom- inating on rewarming with exudation of uid into the Erythrocyanosis tissues. Purple-red remedies rarely work, but the oral calcium channel mottled discoloration is seen over the buttocks, thighs blocker nifedipidine may be useful (p. Cold provokes it and causes an unpleas- blood pressure should be monitored at the start of ant burning sensation. The vasodilator nicoti- erythrocyanosis may be the site where other disorders namide (500 mg three times daily) may be helpful will settle in the future, e. Palmar erythema Widespread This may be an isolated nding in a normal person or Caused by infection (bacterial or viral) be familial. Sometimes it is seen in pregnancy, liver Drug reactions disease or rheumatoid arthritis. Often associated with Connective tissue diseases spider telangiectases (see below), it may be caused by Underlying malignancy (e. Borrelia burgdorferi) Telangiectases This term refers to permanently dilatated and visible or caused by a myeloproliferative disease (e. They appear as linear, punctate cythaemia rubra vera or thrombocythaemia), lupus or stellate crimson-purple markings. The common erythematosus, rheumatoid arthritis, diabetes, degen- causes are given in Table 11. If the diagnosis is in doubt, press on the central feeding vessel with the corner Erythemas of a glass slide and the entire lesion will disappear. Erythema accompanies all inammatory skin condi- Spider naevi are seen frequently on the faces of tions, but the term the erythemas is usually applied normal children, and may erupt in pregnancy or to a group of conditions with redness but without prim- be the presenting sign of liver disease, with many ary scaling. Liver function should viral infections such as toxic shock syndrome and be checked in those with many spider naevi.
Hypertension can result in coronary artery disease purchase prinivil 10mg fast delivery arrhythmia quality services, enlargement of the heart prinivil 5mg lowest price hypertensive urgency, or strokes discount 10 mg prinivil visa blood pressure while pregnant. Sudden attacks of convulsions in pregnant women (eclampsia) purchase prinivil 5 mg without a prescription pulse pressure 36, and other kidney diseases of pregnancy, usually cause high blood pressure. Women have hypertension less often than men until menopause is over; then, soon after, they have it as often. Include oat bran; it appears to be the very best type for the purposes you have in mind. If you are overweight and have high blood pressure, you would do well fasting one or two days a week. Even the visits of friends and relatives may have to be restricted or prohibited for a time. He can give you enabling grace to obey the Ten Commandments and remain true to Him, in spite of the compromise and wickedness in our world. A thrombus is a clot inside the brain which blocks the flow of blood to the brain. Whatever the cause, the result is local brain tissue death from lack of oxygen and food. If the damaged area is small enough, the brain will reroute the affected brain functions to other areas of the brain, as a period of relearning and compensation occurs. Once the damage occurs, supplementation with copper cannot repair it, but the copper can help prevent aneurysms from occurring (2-4 mg/day). Study the Bible, obey it, and do all in your power to be an encouragement and help to others. Later, carefully begin graduated exercises; massage; Cold or Alternate Douche to affected muscles. You then have fat particles in your blood which can ultimately be bad for your heart. Reduce total fat intake to less than 30% of daily calories; but, even better, reduce it to 20%. Cook rice, beans, and other grains without including fat in the cooking or the serving. Eating such simple carbohydrates in the diet are a significant factor in causing people to have high triglyceride levels. Even losing 10 pounds can reduce triglycerides in those who are 20-30% overweight. Ultimately, try to maintain a weight that is not over 5-10% above what is normal for your age-weight range. Walter Kempner discovered that a rice diet would dramatically lower triglycerides. This is a diet of rice and fruit alone, and no other food, for 2-3 days or as long as you can stand to remain on it. Only buy cold-pressed oil never, never hydrogenated oil (even partially hydrogenated oil). Then add a spoonful or two of wheat germ oil or flaxseed oil to the food after it has been dished onto your plate. In this way, you can carefully measure how much you get, and you ensure that the oil was not cooked. The peanut oil has been taken out, and cheap, hydrogenated oils (sometimes lard) is put in its place. Eggs contain a lot of cholesterol (275 mg per egg), yet studies reveal that, in most people, they do not appreciably raise cholesterol levels. Here are other things found to lower cholesterol: barley, spirulina, lemongrass oil, and activated charcoal. Superficial thrombophlebitis: The affected vein can be felt and feels harder than normal veins. It may appear as a reddish line under the skin, possibly accompanied by pain, localized swelling, and tender to the touch. Deep thrombophlebitis: Pain, warmth, and swelling, with possible bluish discoloration of the skin of the limb it is in. The pain frequently feels like a deep soreness that intensifies when standing or walking, and lessens when sitting or, especially, when the legs are elevated. It can be caused by childbirth, infections resulting from injuries to the veins, and operations. Infections in the legs, feet, and toes must be given immediate attention (especially if a fungal origin is involved). The first is superficial thrombophlebitis, which affects a subcutaneous vein near the surface of the skin. But if there is widespread vein involvement, the lymphatic vessels may also become inflamed, and fluids may collect. It affects muscular veins far below the surface, which are much larger, and can often come after confinement. The reduced blood flow can produce chronic venous insufficiency, evinced by pigmentation, skin rash, or ulceration. Even though the person remains in bed until the swelling subsides, it will return slightly when he gets out of bed. If the opening in the vein, in the thigh, is narrowed too much by the phlebitis (and nearly always if it is entirely clogged), varicose veins will appear lower down on the leg. Fibrogen arrives and entraps blood cells, plasma, and more platelets, which make a blood clot to protect the weakened wall. Massage or rubbing may cause part of the clot to be dislodged and pass to other parts of the body, especially the lungs, causing serious damage or death. If there is any possibility that the person might have blood clots, he should not receive massage. Vitamin E dilates blood vessels, reducing the formation of varicose veins and phlebitis. It is not necessary to rest in bed; but, every so often, rest with the leg 6-10 inches above the heart. So request an aisle seat and get up every 30 minutes and walk up and down the aisles. Surgery or prolonged bed rests increase the likelihood that you will have another attack. Elevate the foot of your bed several inches, to reduce venous pressure in your legs. Do not use pillows under the legs, for doing so elevates the knee above the digestive organs and reduces circulation. But those close to the surface (saphenous veins) are ones which develop these problems. Contraceptive medications can induce varicose veins, as well as hormonal vasodilation just prior to menstruation.
Middle age Polgm/m mice display cardiac hypertrophy generic 2.5mg prinivil with visa arrhythmia treatments, impaired systolic and diastolic function to an extent that is even more severe than wild type mice 24 30 months old trusted 2.5 mg prinivil blood pressure medication zanidip. In addition to the decline in cardiac function with age purchase prinivil with a mastercard blood pressure rises at night, increased susceptibility of the aged heart to stress is also likely related to mitochondrial dysfunction purchase prinivil without a prescription hypertension benign essential 4011. Rapamycin has been demonstrated to extend lifespan in model organ- isms including yeast, y, and mouse [85 87]. Long-term rapamycin treatment for 1 year initiated at mid-life reduced hypertrophy but failed to restore systolic function in aged male mice . This was accompanied by restoration of proteomic and metabolic proles to more youthful phenotypes. It functions to maintain protein abundance and quality and supports normal physiological function. Several protein degradation pathways have been implicated in these failures, including autophagy and the ubiquitin-proteosome system. One of the hallmarks of aging hearts is the accumulation of myocardial lipofuscin. This wear and tear pigment is membrane-bound cellular waste that can neither be degraded nor ejected from the cell and is composed of incomplete lysosomal degradation products, predominantly from damaged mitochondria . In normal physiology, removal of damaged mitochondria occurs primarily through fusion and ssion, autophagy and lysosomal degradation. When mito- chondrial turnover is perturbed by changes in the rates of mitochondrial ssion or fusion or alterations in autophagy, the result is an accumulation of damaged and dysfunctional mitochondria. Tissues with accumulated damaged mitochondria may become senescent and cells may undergo apoptosis when a critical threshold of dysfunctional mitochondria have accumulated or when the affected tissue is chal- lenged with an external stress exceeding the cellular functional reserve. Age dependent cardiac hypertrophy and diastolic dysfunction are also accompa- nied by cardiac proteomic changes [90 ]. Normal adult hearts preferentially utilize fatty acids as the main energy source, while diseased and failing heart use glucose as the main energy source. In addition, consistent with age-dependent cardiac hypertrophy, there are increased levels of extracellular structural proteins (and their associated signaling pathways) with age . These changes may be the result of an underlying decline in protein quality control systems, which in turn lead to the accumulation of damaged proteins that are unable to efciently perform their biological roles. As the efciency of protein degradation decreases in old age, it is generally expected that the overall protein turnover rate should be slower in tissues from older individuals. This was supported by early studies performed using the classical method of measuring the bulk rate of incorporation or wash-out of radioactive label in total protein [104, 105]. However, using a novel non-radioisotope deuterated leu- cine labeling method followed by proteomics analysis, recent studies demonstrate that the average proteome turnover rate is not signicantly different in the aged mouse heart . Similar observations have been made in other tissues, including liver  and aged skeletal muscle (Kruse and Marcinek, ms. These studies examine the individual protein turnover rates simultaneously for hundreds of leucine containing proteins and are independent of differences in amino acid precursor pool sizes . The discrepancy between these recent data and earlier ndings might be explained by the greater inuence of abundant proteins in the old bulk protein measurements, or may be due to precursor pool differences. Other recent studies utilizing a similar metabolic labeling-based mass spectrometry approach to assess in vivo protein turnover have observed turnover rates consistent with our observations in aging mice [108, 109]. Thus, while the overall turnover Cardiovascular Disease and Aging 135 rates of proteins are not signicantly different or only slightly slower in the aged heart, the increased prevalence of damaged proteins and decreased efciency of proteostatic maintenance in old age may have a balanced effect on turnover that mediates cardiac aging. Earlier studies suggest the existence of multipotent populations of cells in the heart, such as c-kit + and sca1+/c-kit- cells, that are capa- ble of differentiating into cardiomyocytes following isolation and culture [110, 111]. In contrast, a recent study demonstrates that c-kit + cells only minimally con- tribute to cardiomyocytes regeneration during development, aging or in response to injury . Regardless of their role during normal physiology, these cells are apparently insufcient to prevent the progression of cardiovascular aging or to spontaneously regenerate the heart following acute ischemic events. Possible expla- nations include limited capacity of these cells to regenerate myocardium in the presence of continuous stress (such as pressure overload and ischemia), and the intrinsic aging of cardiac stem cells. Evidence of the latter was provided by experi- ments in rodents, which revealed that cardiac c-kit + stem cells in older animals had a higher rate of apoptosis and shorter telomeres . Interestingly, in diabetic cardiomyopathy all of the above changes were attenuated by the ablation of the p66Shc gene . Studies using cardiosphere-derived cells, another type of cardiac stem cell, also demonstrate a signicant age-dependent decline in the number and function of stem cells derived from mouse atrial explant . Using multi-isotope imaging mass spectrometry to detect 15N thymidine, Senyo et al. Taking into account the multinucleation and polyploidization of adult cardio- myocytes, the estimated turnover rate of cardiomyocytes is 0. Studies have shown that broblasts isolated from old hearts have a lower proliferative capacity and have impaired differentiation into myobroblasts in response to injury [35, 123]. Cardiac broblasts can be derived from several lin- eages including mesenchymal and myeloid origins, and the Entman group has dem- onstrated increased differentiation of these progenitors into mesenchymal broblasts and myeloid broblasts which contributes in increased cardiac brosis in aged hearts [122, 124, 125 ]. These benecial effects clinically translate into protection from hypertensive target organ damage, improvement of chronic heart failure, reduction of atherosclerosis as well as decreased frequency of atrial brillation and stroke. They also showed that aged miR-34a knockout mice have improved contractile function and reduced cardiac hypertrophy compared to wild-type littermates. In the same study, they demonstrated that inhibition of miR- 34a can also improve contractile function in Ku80 knockout mice (a mouse model Cardiovascular Disease and Aging 139 of accelerated aging). These observations suggest increased miR-34a expression in the aged heart contributes to cardiac aging. As atherosclerotic diseases are a leading cause for mortality and morbidity, the mechanisms of vascular aging that have direct rel- evance for atherogenesis are considered, focusing on the role of oxidative stress and chronic low-grade inammation. In the past decade a growing number of publications have revised our understanding of the important role of age-related functional and phenotypic alterations of microvascular endothelial cells, both in the aging process and the development of multiple diseases of aging. Thus, we also review recent insights into the mechanisms of microvascular dysfunction in aging and how these might contribute to age-related functional decline of multiple organ systems. Impaired ow-induced vasodilation likely contributes to decreased exercise capacity and myocardial ischemia in the elderly. Mitochondrial-located Nox4 is a major source of pressure overload-induced oxidative stress in the heart  and its expression is up-regulated in the vasculature of hypertensive aged mice . Thus, the effects of oxidative and nitrative stresses in aging are observed primarily in the vascular endothelium, but also have effects in the vascular smooth muscle cells. Resveratrol was shown to improve endothelial function in hypertensive patients  and to prevent arterial wall inammation and stiffening in nonhuman primates . Vascular inammation in aging contributes to the development of vascular dysfunction [182, 205] and pro- motes endothelial apoptosis in aging [173, 182]. Secretion of inammatory media- tors from microvascular endothelial cells is also likely to affect the function of cells in the parenchyma of the supplied organs. For example, neural stem cells were shown to lie close to blood vessels, and their function is likely directly affected by pro-inammatory changes in the specialized microenvironment of this vascular niche . In this regard it should be noted that age-related functional and pheno- typic alterations of the microcirculation also promote chronic inammation indi- rectly in the brain and other organs.
Thus clearance before signicant infection develops can occur by various scenarios buy prinivil with a mastercard hypertension silent killer. First order prinivil 2.5mg on-line blood pressure supplements, recent stimulation by antigen can boost eector T cell density to protective levels order prinivil with paypal heart attack 42 year old. Stimulation can occur by persistent antigen maintained in the host or by recurrent infection order cheap prinivil line arteria tapada en ingles. Second, slowly spreading infections may allow dierentiation of eector T cells from memory T cells in time to control initial spread of the pathogen. Third, memory antibody may clear the pathogen before the initial infection becomes established. Lack of symptoms during secondaryinfectionmayresultfromrapid clearance of the parasite or from control of the infection that still al- lows some parasite replication and transmission. It is important to dis- tinguish between clearance and controlled infection when studying the population dynamics and evolution of the parasite. In summary, parasite attributes determine the type of host memory that impedes secondary infection. For example, the number of parasites in the inoculum frequently inuences whether an infection is cleared quickly or spreads widely. These various parasite attributes and the rate parameters that gov- ern parasite birth and death within hosts must be measured against the kinetics of immunological memory and the response to secondary infection. The quantitative outcome inuences the selective pressure imposed on various parasite epitopes by host memory. Such selective pressure, in turn, shapes the distribution of antigenic variation in para- site populations. The immunological prole of each host and the variation of proles between hosts inuence the selective pressures imposed on parasite antigens. For the prole of each host, consider as a simple measure of immunodominance the number of epitopes to which a host retains protective antibody. If a host retains protection against n epitopes, then avariantparasite strain must dier in at least n sites to avoid all mem- ory. If the mutationratepersiteis,thenthe probability is n that aprogenyoftheoriginal strain is an escape variant with all of the n necessary dierences. Several laboratory experiments of inuenza have studied the origin of escape variants when neutralizing antibody pressure is imposed against viral epitopes (Yewdell et al. For anti- bodies against only a single epitope, escape variants arise often because only a single mutation is needed. The mutation rate of inuenza is on the order of = 105 per nucleotide per generation. Thus, a moderate- size population of viruses likely has at least a few escape mutants. By con- trast, a more focused immunodominant response allows the rapid evo- lution of escape variants. To determine the selective pressures imposed on parasite popula- tions, the immunodominance of each host s memory prole must be placed in the context of variationinmemoryproles between hosts. A parasite with genotype A/B at the two sites sweeps through the popula- tion, infecting all hosts. One-half ofthe host population maintains mem- ory against both antigens, one-quarter has immunodominant memory against A only, and one-quarter has immunodominant memory against B only. Now consider how this distribution of memory proles inuences the success of antigenic variants. Thism utant can attack the quar- ter of the host population with memory only against B. Asthepara- site spreads, a second mutation to A /B allows attack of the remaining hosts. This example shows that strongly immunodominant host proles lim- ited to one or a few sites allow parasite mutants with few changes to succeed. Once the variant parasite begins to spread between suscepti- ble hosts, additional mutations allow attack against hosts with dierent immunodominant proles or against hosts that developed broader im- munity against multiple antigenic sites. Inuenza evolution may proceed by this sort of sequential accumula- tion of variation, with new epidemic strains diering from the previous epidemic strain at several sites (Natali et al. In the laboratory, studies show that individual mice infected with hu- man inuenza often produce antibody responses focused on a limited number of antigenic sites probably just one or two sites (Staudt and Gerhard 1983; Underwood 1984; Thomas et al. Individ- ual variation in antibody response probably occurs because stochastic recombinational and mutational processes generate antibody specicity (Staudt and Gerhard 1983). Surveys of human populations nd that individuals previously ex- posed to inuenza vary in antibody memory proles (Natali et al. For samples collected from the early years of the Hong Kong inuenza subtype epi- demics (1969 and 1971), 33% of individuals had antibodies to all three sites, 50% had antibodies for two sites, and 17% hadantibodies for only one site. Approximately equal numbers of individuals lacked antibody to any particular site, suggesting that each site was equally likely to stim- ulate an antibody response. It appears that after several years of repeated exposure to various strains of the Hong Kong subtype, individuals had acquired a wider repertoire of antibodies. Human children tend to have particularly narrowly focused antibody prolesagainst inuenza (Natali et al. This may occur either because of children s relatively smaller number of exposures or because of their narrower response per infection. Theseobservations on mice and humans support the hypothesis that individuals have narrowly focused antibody memory and that individu- als vary in the antigenic sites to which they respond. This combination of individual focus and population variability creates a heterogeneous pat- tern of selection onparasites. After a widespread epidemic by a single parasite type, the parasite must acquire several new mutations before it can again spread widely through the population. Stepwise changes can occur by rst changing at one site and attacking a subset of the population with a dominant response against that site. However, the immunodominance of individual hosts for particular epitopes and the population variability of immune proles can create important se- lective pressures on parasites. Suppose, however, that a host rst de- velops a memory response to a particular antigen, and then is exposed secondarily to a variant ofthatantigen. Amemoryresponse to the rst antigen rather than a primary response to the variant is called original antigenic sin. Amemoryresponse based on previously encountered, cross-reactive antigens has three consequences for the immunological structure of host populations. First, cross-reaction may aid protection or clearance against secondary challenge. This occurs if the cross-reactive memory eectors have sucient anity for the variant antigen (Kaverin et al. This occurs when cross-reactive memory eectors do a poor job of clear- ing secondary challenge but respond suciently to repress a new, pri- mary response against the variant antigen (Good et al. Third, the host may fail to develop an increasingly broad memory prole over the course of repeated exposures to dierent variants. Ihavealready mentioned the immunodominance of individual immune proles and the tendency for the pattern of immunodominance to vary among individuals. I also discussed how cross-reactivity can aect clear- ance of secondary challenge and the development of memory over a host s lifetime.
Amiodarone and procainamide are occasionally used to convert atrial flutter in situations where cardioversion has failed or is contraindicated generic 5 mg prinivil fast delivery blood pressure chart systolic diastolic. One disadvantage of using drugs to treat atrial flutter with 2:1 conduction is that the atrial rate slows before terminating discount prinivil 2.5mg with mastercard pulse pressure in neonates. A patient with 2:1 conduction at atrial rates of 300 bpm may have 1:1 conduction once the atrial rate has slowed to 240 bpm trusted 2.5mg prinivil blood pressure keeps going up. Management Overview of Tachyarrhythmias Tachyarrhythmias can be challenging to diagnose in children purchase prinivil 5mg on line blood pressure medication good for acne. The sinus node is capable of achieving rates in the low 200s and occasionally as high as 230 bpm. Sinus tachycardia at rates above 180 bpm is often seen in infants and young children with fever or agitation. Assessment of vital signs and overall condition is the first and most important step in arrhythmia diagnosis and management. Truly unstable or pulseless tachyar- rhythmias should be treated with prompt cardioversion. A fast tachyarrhythmia of any kind will eventually lead to congestive heart failure and decreased myocardial contractility. Patients who present 12 24 h after arrhythmia onset often complain of shortness of breath and fatigue and may have low blood pressure. As in other forms of cardiogenic shock, intravenous fluid boluses may worsen symptoms and should be avoided. Adenosine is an invaluable tool for the treatment and diagnosis of supraven- tricular arrhythmias (Table 32. This is best accomplished with the use of a T connector that allows the adenosine and the flush to be attached simultaneously so the flush can be given immediately following the adenosine. In patients with heart failure or patients who have developed heart failure from a pro- longed tachyarrhythmia, larger doses of adenosine may be required and lon- ger times (up to 20 s) may be observed from the time of injection to the observed effect. Patients almost always have sinus tachycardia for 1 2 min following adenosine administration, which is possible secondary to pain. Patients with atrial flutter and 2:1 conduction may experience 1:1 conduction during the 1 2 min post-adenosine catecholamine surge with a resulting doubling of the heart rate. Junctional rhythms that slightly exceed the sinus rate are relatively benign and are referred to as Accelerated Junctional Rhythms. Recognition clues: A narrow complex tachycardia with no visible P waves Usually regular, but may be irregular. Causes: Accelerated junctional rhythms are idiopathic and for the most part benign. In severe cases, amiodarone or procainamide are used, sometimes in combination with ice to cool the patient s core temperature. In the pediatric population, ventricular tachycardia usually occurs in children without structural heart disease or ventricular dysfunction. Management: Cardioversion is the treatment of choice for patients who are pulseless or unstable. Causes: Electrolyte disturbances Idiopathic Misplaced central venous lines or intracardiac devices with the tip in the atrium (typically right atrium) Common in newborns Inotropic infusions (epinephrine, dopamine, etc. A thorough workup for underlying electrolyte abnormalities or structural heart disease should be performed before deeming the problem benign. Antiarrhythmic drug ingestions should be considered, particularly in toddlers, and one should inquire about bottles of antiarrhythmic drugs in the household. Blood cultures have been negative and the antibiotic course will continue for 2 more days. The child appears stable with no change in respiratory rate, blood pressure, or oxygen saturation. On examination, the capillary refill was slightly prolonged, peripheral pulses were 1+ with rapid heart rate. No hepatomegaly noted, heart sounds indicated tachycardia; murmurs were too difficult to appreciate in view of tachycardia. It is advisable to obtain a pediatric cardiology consult for further assessment and follow-up. The child should be started on maintenance antiar- rhythmic therapy (usually digoxin or propranolol) and monitored in the hospital for 48 h after starting therapy to ensure that tachycardia does not recur. Also, the parents should be counseled on how to check the infant s heart rate at home because the baby will not be able to communicate the feeling of palpitations in the event of a recurrence. Case 2 A 2-month-old infant was seen by the primary care physician for a well child care visit. Mother says that the child is doing well; however, she noticed that he tends to sleep more and feed less than her previous child. Mom did well during gestation except for rash and joint pain which resolved spontaneously. Heart rate was 45 bpm, regular, respiratory rate was 45 min and oxygen saturation was 95%. Capillary refill was slightly prolonged and pulses were 1+ throughout all four extremities. The precordium reveals forceful heart beats; however, bradycardia is again noted through palpation of the chest and auscultation. Congenital complete heart block is suspected and the mother underwent investi- gative studies for lupus erythematosus which were positive. The child was admitted to the intensive care unit where he received an implanted pacemaker to improve the heart rate. The mother was advised to undergo fetal echocardiographic evaluations of future pregnancies. The young man complains that he experiences irregular heartbeats with occasional heavy beat. The young man is a member of the high school football team and is seeking clearance to continue on the team. Blood pressure in right upper extremity was 110/70 mmHg and in the right lower extremity was 112/67 mmHg. The mucosa was pink with good peripheral pulses and perfusion 32 Cardiac Arrhythmias 383 Fig. Precordium was quiet with normal right and left ventricular impulses and no palpable thrill. The history and physical examination were suggestive of premature atrial or ventricular complexes. A treadmill stress test was also performed which again shows premature ventricular contrac- tions, with uniform morphology and resolution with exercise, all consistent with benign premature ventricular contractions.
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