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In its wake cheap glycomet 500mg without a prescription metabolic disease hyperparathyroidism, it has brought a number of people who purport to be able to cure allergies through the use of various kinds of diet buy glycomet mastercard diabetes mellitus lada. This is one approach order glycomet online diabetes prevention graphics, but it is not supported by the weight of scientific and medical 22 thinking buy discount glycomet 500mg managing diabetes with diet. When Dr Gray moves on to discuss other ideas associated with nutritional medicine, she is dismissive. Some claim that a rise in pulse rate is a strong indication of a reaction to food; some use the idea of allergy or intolerance as an underlying cause of diseases like multiple sclerosis and rheumatoid arthritis; some use diet as part of a form of therapy to be given to any patient who is not responding to other forms of treatment. None of these theories seem to warrant serious 23 consideration, partly (but not only) because they are not based upon conventional science. They pay no heed to the fact that a proper medical assessment might disclose (as it has done in some cases) illnesses that require a completely 24 different and specific form of treatment. When the British Nutrition Foundation was set up in 1967, it had the American organisation as a model. Its first and major sponsors were the sugar refiners Tate and Lyle and the flour 25 millers then known as Rank. Professor Ian Macdonald illustrates well the links between industry, academia and the government. A good example of this is what happened following the publication of the joint Royal College of Physicians and British Nutrition Foundation Report on Food Intolerance and Food Aversion. While this sounds like a good idea and one step towards a standard labelling system, which would enable the lay consumer to see at a glance if a product were likely to cause an allergic response, the recommendation goes on to say that only doctors and dieticians should have access to such a database. This recommendation, by its very wording, begins to set the tone for the kind of project which eventually came to fruition. After all, thousands of ordinary people suffer from allergies and food intolerance; should they not have easy access to lists of chemicals in food which might damage their health? The recommendation and its implementation were not turned over to an acceptable academic or policy making body, or even a government department. Its scope was limited and it did not approach even the most rudimentary scientific analysis of allergy-producing foods. It is a list of products under different headings which contain ingredients known to cause food intolerance or allergy. Such a database is quite clearly more than useless to any one who Deeds to take charge of, or educate themselves about, their own illness. Because the monitoring is voluntary, and the information is given by the food industry, it is highly restricted in its coverage of foods and not the product of a serious research initiative. In March 1985 an article appeared in the Guardian, based on a chapter of a book to be published in 1986 by Cambridge University Press. Nowhere in the article was any link between Dr 28 Gibney and the sugar industry explained. In Britain, the organisation best equipped to deal with such matters is the British Nutrition Foundation. Chapter Twenty Wellcome, Part One: A Powerful Concern 1 For gifts blind the eyes of the wise and pervert the words of the righteous. Over the last half century, medical education and research in Britain have been dominated by the interests of Wellcome and Rockefeller. In 1911, three years after his report had radically re-structured medical education in America, Abraham Flexnerf travelled to Europe and wrote a 2 second report on medical education. This Commission, which sat for two years between 1910 and 1912, formulated a new constitution for London University and recommended the reform of medical 3 education in London. In 1921, Rockefeller created a new School of Hygiene and Tropical Medicine as part of London University. The School was set up after tripartite discussions between Rockefeller representatives, the British government and London University. Between 1922 and 1927, the Rockefeller Foundation donated approximately half a million pounds to the new School, which 5 was formally opened in 1929, incorporating the older London School of Tropical Medicine. Rockefeller influence and money in London linked the major London hospitals to London University, creating one of the largest medical teaching and research complexes in the world. University College, University College Hospital Medical School and University College Hospital were all drawn together and between 1920 and 1923 the University College Hospital Medical School received nearly one and quarter million pounds from the Rockefeller Foundation. It was this re-structuring which radically changed the nature and the direction of medical research in Britain. Scholarships enabled leading figures in the administration of medical research to spend time in America observing American medical research and teaching. The Medical Research Council was an organisation much used by Rockefeller administrators to tutor British scientists and medical administrators in the American way. By 1939, the Rockefeller Foundation had supported 131 6 British Fellows through the Medical Research Council, at a cost of some £65,000. By 1950, there were former Fellows who had received Rockefeller money in 31 professorial chairs in British medical schools. Such fellows were inevitably favourably inclined towards scientific medicine and in many cases their work was linked to pharmaceutical companies. It was not until the mid-thirties that British-based Foundations and Trusts began to take an interest in medical research and education. The first sizeable British-based intervention came from Lord Nuffield, who gave two million pounds for the development of clinical research at Oxford. Any initial private medical research funding in Britain was soon to be eclipsed when the Wellcome Trust came into being in 1936. Wellcome and Rockefeller interests came together first in the teaching about, and research into, tropical illness. By the late fifties, the Wellcome Trust and the Rockefeller Foundation had established common policies in medical research and teaching. In the post-war years, overlapping personel on their boards, and similar interests in scientific medicine led gradually to the Wellcome Trust taking responsibility for the parts of London University complex which had previously been funded by Rockefeller. The fact that both Burroughs and Wellcome were Americans inevitably dictated the nature of the Wellcome corporation. Now one of the most powerful of the British multinationals, the Wellcome Foundation is particularly powerful because its multinational axis is Anglo-American. The corporation has built upon and concretised many of the older political, cultural and social power structures which straddle the Atlantic. The company which produces the pharmaceuticals is now called the Wellcome Foundation; its operations include production sites at Beckenham, Berkhamsted and Dartford, and a sales and technical enquiries centre at Crewe. The Wellcome Trust is also situated in Euston Road, in a large Victorian building which has recently been refurbished as a life science centre. There is a series of academic and administrative units, in London and other major British cities, either wholly or partly supported by the Wellcome Trust, the function of these units varying from research to teaching and charity administration. The Wellcome Trust, set up as a charity on the death of Henry Wellcome in 1936,t is now one of the biggest medical research funders in Europe. Up until 1986 the Trust controlled 100% of the shares of the Wellcome drug producing company.

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Beta rhythm is usually of lower voltage than alpha cheap 500mg glycomet fast delivery managing diabetes hot weather, is present normally buy glycomet 500 mg without prescription diabetes type i definition, but increases with concentration purchase discount glycomet blood sugar 110, anxiety discount glycomet 500 mg without a prescription xanax blood glucose, or minor tranquillisers; it replaces alpha rhythm during stimulation or when the eyes are opened; best seen over mid-scalp (somatosensory/motor cortex). Theta & Delta are usually absent in healthy, alert adults, are a normal finding in children, in everyone as they enter deep sleep, and in many people with fairly minor problems, e. If diffusely present over the brain, slow activity may indicate a degenerative or metabolic disorder, but, when localised, may indicate a discrete cerebral lesion, but its absence does not exclude such a lesion. Mu rhythm, found in the precentral region, lies within the alpha range and is reduced by moving (or thinking about moving) the contralateral limbs. Gamma rhythm (up to 100 Hz) are thought to represent the coming together of different neuronal networks to allow cognition or movement. Fp1 or left frontal pole, P4 or right parietal, C means along a central line between the ears, Fz is frontal along the vertex or a line from nose to occiput, and Pg 1 and 2 are left and right nasopharyngeal, etc. The study of the gamma band is relatively new and followed discovery of its functional significance in intracerebral recordings. Light ea, 2006) Coherence refers to a comparison of the periodicity of a particular frequency between two locations and research using analysis of coherence suggests that circuitry is abnormal in Parkinson’s and Alzheimer’s diseases. Sphenoidal electrodes (less often used today than heretofore) record discharges from the temporal lobes. Nasopharyngeal leads are not thought to add much to scalp recordings and can be very uncomfortable. Although electrodes F7 and F8 are known as anterior temporal leads they lie over frontal areas; nevertheless, they reflect mostly anterior temporal lobe activity. More accurately, anterior temporal activity can be recorded by tracing a line between the external meatus and lateral canthus and putting the electrode one cm above a spot one third of the distance forward from the meatus. During surgery it becomes possible to record directly from the surface of the brain, so-called electrocorticography. They can be synchronous or asynchronous, depending on whether they appear in corresponding leads. Even the localisation of an abnormal electrical discharge is not a universal indicator of lesion site. Hill (1952) found that psychopaths (especially those with a history of impulsive homicide) had evidence of ‘delayed’ cerebral maturation (bilateral rhythmic theta activity in central and temporal regions, alpha variants, and episodic posterior temporal slow-wave foci). The finding of slow waves should not be too readily passed of as indicative of ‘electrical immaturity’. The testing condition 346 that has most consistently revealed hypofrontality (prefrontal cortical hypofunction) in schizophrenia is the Wisconsin Card Sorting Test. This, they suggested, might reflect dysfunction of the recurrent inhibitory drive on auditory neural networks. Numbers are an average of the time in milliseconds passed 349 between stimulation and appearance of a component, e. The P300 latency is prolonged in depression and reflects 350 a diminished ability to attend, which in turn may be dependent on serotonin. The P50 is thought to index early gating of incoming sensory data (abnormal in most, but not all, schizophrenic subjects; also abnormal in their clinically healthy relatives; linked to polymorphism in alpha-7 nicotinic receptor). Researchers have looked at P50 abnormalities as a potential endophenotype for schizophrenia. When 2 clicks separated by 200 msec are presented the patient the amplitude of the P50 wave following the second click should be smaller than that after the first click. In some cases of schizophrenia both waves are of equal amplitude, indicating a possible failure of sensory gating. To some degree this abnormality may be related to polymorphisms in or near the alpha-7 nicotinic receptor subunit gene (chromosome 15). Some panic attacks occur at night, especially during the transition between stages 2 and 3 when dreaming is absent and cognitions are minimal. Most people have a number of brief awakenings during sleep but may not recognise them as such unless they persist for more than a couple of minutes. Humans tend to take all the day’s sleep in one go (100% consolidation) whereas guinea pigs sllep in short bouts spread throughout the 24-hour period. The sleep cycle does not lengthen until adolescence, when the 90-minute cycle of the mature adult is achieved. K-complexes are said to resemble the letter K: high amplitude biphasic waves, the first component being negative. K-complexes can be invoked during light sleep by ambient noise and may represent efferent cortical signals that travel to thalamus and brain stem. The spindles are complexes of increasing and then decreasing amplitude (12-14 Hz). Ejaculation occurs in response to dreams of a sexual content but the erection as such is content neutral. Therefore they experience a phase shift advance, the normal circadian rhythm having been brought forward in time. After a few sleepless nights a person becomes confused, incoherent and irrational. Interestingly, combining fluoxetine with the hypnotic drug eszopiclone was associated with greater improvement in depression scores than when fluoxetine was given alone, and such improvement was not explained by better scores on sleep items within the depression scales. The nadir (lowest point) of body temperature occurs in the second half of sleep; maximum body temperture occurs in the afternoon. Cortisol is produced in bursts throughout the night, reaching a daily maximum at c. For example, Allen ea (1991) failed to find a significant difference in the lateralisation of tactile-evoked potentials when a stimulus was evoked to the index fingers of patients with schizophrenia and age- and sex- matched controls. P3 (P300) abnormalities (showing differences from controls) have been reported in schizophrenia, behavioural problems,(Iacono ea, 2002) memory disorders like Alzheimer’s disease, attentional disorders, and, as a trait marker, in the offspring of alcoholics,(Polich ea, 1994) and in affective disorders (Hall ea, 2009); abnormalities may involve amplitude, latency or the positioning of the peak over the head. The subject looks at a smoothly moving target, such as a pendulum or a moving spot. Excess jerkiness - a disrupted, jagged pattern - is found in most, but not all, schizophrenic subjects, in about 45% of their parents and siblings - who may not have overt illness, and in around 8% of the general population. According to Kathmann ea,(2003) over 80% of have abnormal smooth pursuit tracking with about one in three of their relatives having similar problems. Saccades These are fast, ballistic eye movements that bring the fovea centralis and the target together, e. The eye may jump ahead of the target (anticipatory saccades) or, because of reduced gain (speed of eye v speed of target), the eye falls behind the target and uses a catch-up saccade to bring it back to the target. Antisaccades A subject is asked to fixate a central dot that steps at random to left or right. When the target steps into the periphery the subject is asked to look away from the target to the opposite side. It requires inhibition of the temptation to look to the side where one remembers the target to be: when one must inhibit the reflex to look toward a light (prosaccade) and instead consciously look in the opposite direction (antisaccade), schizophrenic subjects have great difficulty not turning their eyes to the light. Xenon is an inert gas that does not affect physiological or biochemical processes.

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The Varieties of Medicine 63 Figure 6 is a reproduction of fingerprints photographed by Thelm a Moss and Kendall Johnson purchase line glycomet diabetes prevention recognition program, who are conducting research on radiation photography at the Neuropsychiatric Institute at the University of California at Los Angeles buy generic glycomet canada diabetes mellitus type 2 brochure. This held apparently varies in relation to certain stimuli cheap 500 mg glycomet with amex diabetes symptoms nerve pain, including bodily manipulations or interventions 500mg glycomet visa blood sugar normal, and possibly with thought processes. According to acupuncture theory, energy in the body courses through specihc points along bodily meridians. In a healthy organism, the “energy” How is unim peded and ac­ cordingly the body is in a state of equilibrium. However, if the energy flow becomes blocked, or promiscuously released, acupuncture—the insertion o f needles at various acupunc­ ture points—can be utilized to reestablish equilibrium. T hrough the reestablishment of equilibrium, acupuncture apparently alters the body’s energy held. T he picture on the right shows the same hnger after an acupuncture needle had been inserted in the subject’s upper arm and left there for 5 minutes. It seems clear that the hum an body is surrounded by a “field,” but we do not fully ap­ preciate the significance of the heightening in the body’s energy field that results from acupuncture. T here is evi­ dence that acupuncture works, however, and we can assume that its efficacy might be related to its effect on the body’s energy field. T he purpose of this illustration, then, and o f the other illustrations in this section, is not to dem onstrate that al­ lopathic medicine is wrong, but rather that it is fallible. T he work o f Johnson and Moss with radiation photography sug­ gests that there is a “life” or “energy field” surrounding the hum an body. This fact alone, if convincingly established, will not repudiate allopathic theory. But it will be evidence that there is a newly discovered phenom enon—the energy field—which m ight serve as an indicator for use in diagnosis and healing. T here no longer is m uch doubt that it works —doubts are only expressed about how it works. This is ironic, since there is no generally accepted theory of anes­ thesia in allopathic practice. Andrew Weil, a physician and drug researcher, describes the anomaly: alth o u g h anesthesia has been a ro u n d fo r over a h u n d re d years a n d alth o u g h m illions o f persons have been p u t into th e state u n d e r close observation, no satisfactory theory o f g en eral anes­ thesia exists; doctors have no idea w hat these d ru g s do to th e brain that accounts for th e state. In part, it is attributable to the inflexibility of allopathic prac­ The Varieties of Medicine 65 tice, its intolerance of inconsistencies. This is not surprising since all paradigm s—and allopathy is a rigid paradigm —elicit extraordinary loyalty. In tests perform ed at the M enninger Clinic in Kansas, Chief Rolling T hunder, a Shoshone medicine man, was asked to “cure” a contusion on a subject’s leg. He placed his m outh over and around the bruise, sucked vigorously, then dashed to the opposite side of the room and vomited. T he bruise disappeared at roughly the same time that the scientists in the room rushed to retrieve the vomitus. T o the scientists, the “cure” could only have been effected if the dam aged tissue in the bruised leg had somehow been physically extracted. O f course, it was not removed in the sense in which the scientists could have understood it. To the subject and the Chief, the sucking and the vomiting were elements of dram a underpinning a belief system—a belief that a cure could be achieved. T he two groups perceived the episode differently, and the explanation for the cure may lie in this perceptual difference. A cupuncture practice is inconsistent with W estern medical theory in several ways. T o begin with, for an operation to be perform ed on any part of the anatomy, acupuncture needles may be placed in different parts o f the body for different patients. In one hospital the needles might be inserted into the forearm s, while in a second, the placement points might be the neck and the ankles. Accord­ ing to the allopathic theory of pain—the specificity theory —this makes no sense. U nder allopathic theory, specific points in the body receive and transm it signals to the brain. T he theory dictates that the person will experience pain precisely at the point o f the stimulus. The manipulation of acupuncture needles is designed to restore harm ony to the body. In both 1971 and 1972, the American Academy of Parapsychology and Medicine sponsored interdisciplinary symposiums respec­ tively entitled “The Varieties of Healing Experiences: Exploring Psychic Phenom ena and Healing,”52 and “T he Dimensions of Healing: A Symposium. Two of the m ore fascinating, but problematic, reports feature Arigo, a natural healer from Brazil, who is now dead; and bodily control m anifested by the Swami Rama, an Indian yogi who dem onstrated his yogic training program under carefully controlled laboratory conditions at the M enninger Founda­ tion clinics. Arigo, an uneducated natural healer, saw thousands of patients in the course of his work. His diagnostic skills were carefully m easured against diagnosis rendered for the same patients by allopathic physicians, and com pared well with them. Arigo generated his diagnosis without the use of sophisti­ cated technology, largely on the basis of visual scans of a patient. A lthough he utilized some m odern techniques such as drugs, and occasionally perform ed surgery, his repertoire also included surgical repair without the use of any equipm ent. U nder similarly controlled conditions, the Swami also dem onstrated his ability to stop his heart from beating. After he was “wired” for the dem onstration and told to proceed, the electrocardiograph records re­ flected an increase in heart rate from 70 beats per m inute to about 300 per minute. T he experim enters had expected the heart rate to stop altogether and thus thought that the ex­ perim ent had been a failure. A fter a final examination of the records, the investigators concluded that the Swami had stopped his heart for at least 17 seconds. The growing literature on biofeedback contains unmistakable implications for self-care. A lthough we have achieved an e x trao rd in ary am o u n t o f sophistication in d ru g an d surgical th erap y in w estern m edicine, this developm ent has been a bit unbalanced. W e have alm ost forgotten th at it is possible for th e “patien ts” themselves to learn directly to low er th eir blood p res­ sure, to slow o r speed th eir heart, to relax at will. Stoyva and Budzynski have been investigating the use o f biofeedback to “decondition” or “desensitize. If an individual can be trained to exercise control over some bodily functions, self- healing and self-restoration are possible. The evidence assembled thus far suggests that everyone can “learn” to exercise some degree of control. T he psychic surgeon appears to perform surgery without instrum ents and can, in certain instances, penetrate the body wall with his hands.

With a single occupant trapped in a car on all four wheels purchase glycomet australia diabetes medications history, with good access and a well-trained team buy glycomet once a day diabete test, 20 minutes is a reasonable target for releasing the casualty using a standard A-plan approach purchase glycomet in united states online diabetes insipidus medications cause. It is useful for the rescue team order cheapest glycomet and glycomet diabetes type 2 burning feet, having assessed the situation, to agree a target time for A-plan and B-plan options. Large vehicles The principles for rescuing a casualty from a large vehicle such as a heavy goods vehicle are largely the same as for a car. The extrication team will often require heavier cutting and lifting equipment to deal with the heavier vehicle and its structure. This may necessitate the dispatch of specialist rescue units which can impact on extrication time. Removal of the patient from the vehicle A-plan casualty removal When following an A-plan, the roof of the vehicle is often removed to give better access to the patient. If not possible earlier, an assessment of leg entrapment is usually made once the roof is off. If trapped by the dashboard of the vehicle, then space may be made with a ‘dash-lift’ or a ‘dash-roll’. Once the legs are free, a long-board is slid down between the patient’s back and the back of the seat. The board is then held upright with the patient braced against it while the seat back is lowered back as far as possible. Additionally, if the mechanism is still intact, the whole seat may slide back horizontally creating more space. Tricks of the trade Typical roles during the movement of the casualty along the Positioning the long board can be made easier by first sliding two rescue board include: ‘tear-drops’ down behind the patient’s back. The long board is then guided between these, which act as introducers, making the process • manual in-line cervical stabilization (this person in control) easier and often more comfortable for the patient (Figures 21. With very little space and so many roles, think about temporarily disconnecting lines and cables. Once the patient is lying full-length against the board, it is lifted to the horizontal position and then slid out the back of the vehicle. During the release of the casualty on a long-board, there is often a lull when the board becomes horizontal while the patient is strapped to it for ‘control’ or ‘safety’. Strapping and blocking the patient on the board while half out of the vehicle is often precarious, takes time and can be poorly controlled. When the patient arrives at the reception area, they will need to have a full primary survey which necessitates strap removal anyway. B-plan casualty removal The B-plan removal of the casualty is often done through the side door of a vehicle and follows similar principles of command and control. By its nature it tends to be much brisker and with less space so control is rarely as optimal as the A-plan approach. In the usual scenario, a rescue board is slid onto the patient’s car seat and braced to provide a horizontal platform. The patient is then rotated and laid down on the board before being moved up along its length. Tricks of the trade The scenario of a patient suspended upside down in a seatbelt can be particularly challenging. In practice the best solution is probably any that minimizes the time the patient is suspended while providing cervical spine protection as best as possible. Sometimes a firefighter can crawl below the patient’s lap area, on their hands and knees, to support the patient as they are released from their Figure 21. Once free, they are usually extricated as a B-plan option on a long board through the side of the vehicle. The long board used for extrication of casualties is not designed Post-extrication care as a transport device, but may be acceptable for very short journeys. Once free, the patient should be taken to a pre-designated casualty Patients can often be packaged more comfortably and securely on reception area. This is typically 5–10 metres away from the crashed a ‘scoop-stretcher’, which can also help minimize rolling required vehicle and can be prepared in advance with ambulance trolley, when transferred at hospital. At the casualty reception area a rapid reassessment of the patient is made and immediately necessary interventions carried out. This involves securing them onto the trolley with formal spinal immobilization and monitoring, The management of entrapped patients is challenging and com- and protection from the cold. The multi-agency rescue team can develop skills by training in transit then this is preferable in order to minimize further regularly together in order to develop skills leading to safe, efficient on-scene delay. Trauma: Extrication of the Trapped Patient 117 Further reading Tips from the field Calland V. Extrication of entrapped • Communicate with other emergency personnel and agree a target victims from motor vehicle accidents: the crew concept. Eur J • Minimize unnecessary medical intervention in the vehicle Emerg Med 1996;3:244–246. International Cardiac Arrest Guidelines Initial actions Introduction If the victim is unresponsive and not breathing or only having occa- Since the original publication of successful closed-chest cardiac sional gasps, immediately call for help and activate the Emergency compressions by Kouwenhoven, Knickerbocker and Jude in 1960, Medical Services or appropriate Resuscitation Team. If unknown, use interposed breath being delivered every 6–8 seconds (8–10 breaths the maximum available energy setting, or use 360 joules if the per minute). Once an advanced airway is the administration of vasopressors and antiarrhythmics can be in place, continuous chest compressions can be performed, with an considered. Hypothermia Toxins 5 Back-up facilities – Seldom in the prehospital environment is Hypo-/hyperkalaemia Thrombosis (cardiac) there a wide variety of extra equipment (or range of appropriate Hydrogen ion imbalance Thrombosis (pulmonary) sizes) easily available, no extra personnel to back one up in a desperate situation, and no security personnel to protect one in a volatile situation. If possible, for example, place routinely recommended, as absorption via this route is unreliable the defibrillator at the left side of the patient. Space around the adrenaline, amiodarone may be administered intravenously patient is often very limited. For torsades de pointes or suspected hypomagnesaemia, give 1–2 g of poor address information, can be challenging. A meticulous search for reversible causes The success of prehospital resuscitation is pivotal upon early and correction thereof is paramount. However, when The exhilaration and urgency of prehospital emergency care is the cause of the arrest can only be treated in-hospital, or when nowhere more tangible than when confronted by a cardiac arrest extenuating or particularly reversible conditions warrant prolonged victim. Prehospital cardiac arrest in the trauma 2 Equipment – The only equipment you have is the equipment victim you carry. This means that one’s kit must be well prepared, checked and cleaned prior to Introduction the call-out. Ideally the emergency bag should be packed exactly victim is generally associated with low survival rates. Cardiac Arrest 121 4 Breathing techniques The administration of supplemental oxygen to the traumatic cardiac arrest victim is mandatory as these patients are inevitably hypoxic from cardiac and/or respiratory causes. In addition to positive pressure ventilation and chest compres- sions, the following should be considered: ◦ Closure of open chest wounds and control of active bleeding. Should administration, relief of pericardial tamponade, or even open car- emergency thoracotomy be performed, fluid administration diac massage via emergency thoracotomy. It is therefore necessary, may be undertaken via the right atrium directly if necessary. Evidence of need to be administered in order to maintain the patient in a longstanding death such as rigor mortis, dependent livido or state of adequate anaesthesia prior to transport to the receiving putrefaction are obvious indicators of futility.